Top Guidelines Of https://nvesatim.info/
Top Guidelines Of https://nvesatim.info/
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Ako imate bilo kakvo dodatno pitanje vezano za primenu ovog leka, pitajte Vašeg lekara ili farmaceuta.
The carcinogenic probable of filgrastim products has not been researched. Filgrastim did not induce bacterial gene mutations in both the presence or absence of a drug metabolizing enzyme technique. Filgrastim experienced no noticed impact on the fertility of male or feminine rats at doses around 500 mcg/kg.
Go ahead and take prefilled syringe out from the refrigerator 30 minutes just before use and permit it to achieve place temperature right before making ready an injection.
The most tolerated dose of filgrastim goods has not been identified. In filgrastim scientific trials of individuals with cancer receiving myelosuppressive chemotherapyâ???WBC counts > one hundredâ???00/mm³ have already been documented in below 5% of patientsâ???but weren't connected with any documented adverse clinical consequences. mikrograma/kg/dan) i blago smanjenje stope preživljavanja (a hundred mikrograma/kg/dan).|Nivestym (filgrastim-aafi) can be a leukocyte expansion variable indicated to: reduce the incidence of infection??as manifested by febrile neutropenia??in people with nonmyeloid malignancies receiving myelosuppressive anti-cancer medications associated with a substantial incidence of significant neutropenia with fever; lessen the the perfect time to neutrophil Restoration plus the duration of fever, next induction or consolidation chemotherapy treatment of patients with acute myeloid leukemia (AML); lessen the length of neutropenia and neutropenia-connected medical sequelae??e.|Adverse events with ??2% greater incidence in filgrastim individuals compared to placebo and connected with the sequelae in the underlying malignancy or cytotoxic chemotherapy integrated diarrhea, constipation, and transfusion reaction.|Neupotrebljivi lekovi se predaju apoteci u kojoj je istaknuto obaveštenje da se u toj apoteci prikupljaju neupotrebljivi lekovi od građana. Neupotrebljivi lekovi se ne smeju bacati u kanalizaciju ili zajedno sa komunalnim otpadom. Ove mere će pomoći u zaštiti životne sredine.|Obično su asimptomatski slučajevi splenomegalije i rupture slezine zabeleženi kod pacijenata i zdravih donora nakon primene filgrastima. Pojedini slučajevi rupture slezine bili su sa smrtnim ishodom. Zbog toga veličinu slezine treba pažljivo pratiti (npr. kliničkim pregledima, ultrazvukom).|Svaki napunjeni injekcioni špric ima pričvršćenu iglu zaštićenu štitnikom za iglu koji sadrži epoksipren, derivat lateksa (prirodne gume), koji može doći u kontakt sa iglom.|Ako dođe do gubitka odgovora ili neuspeha u održavanju odgovora na terapiju filgrastimom, Vaš lekar će ispitati razloge zbog čega se ovo dogodilo uključujući i mogućnost da su se razvila antitela koja neutrališu aktivnost filgrastima.|uočite natečenost lica ili zglobova, primetite krv u mokraći ili braonkasto prebojenu mokraću ili primetite da mokrite manje nego obično (glomerulonefritis),|Lek Nivestim se NE SME primeniti ukoliko je bio izložen temperaturi zamrzavanja duže od 24 sata ili je zamrznut više od jednog puta.|Rupture or enlargement from the spleen may possibly arise. Signs and symptoms consist of remaining higher quadrant abdominal agony or still left shoulder ache. Recommend sufferers to report discomfort in these areas to their physician straight away [see WARNINGS AND Safeguards].|Kod pacijenata sa klinički značajnom preosetljivošću treba trajno prekinuti primenu leka Nivestim. Ne treba primenjivati lek Nivestim kod pacijenata kod kojih u anamnezi postoji reakcija preosetljivosti na filgrastim ili pegfilgrastim.|Pokazano je da primena filgrastim-mobilisanih PBPC smanjuje težinu i dužinu trajanja trombocitopenije nakon mijelosupresivne i mijeloablativne hemioterapije.|Preporučuje se redovno praćenje broja trombocita i hematokrita. Potreban je poseban oprez kada se, sami ili u kombinaciji, primenjuju hemioterapeutski lekovi za koje se zna da uzrokuje tešku trombocitopeniju.|Lek Nivestim je jedan iz grupe lekova koji stimulišu stvaranje belih krvnih zrnaca. Vaš lekar mora uvek da vodi tačnu evidenciju o leku koji ste primili. Drugi lekovi i lek Nivestim}
Kod skotnih ženki pacova, nije uočena toksičnost za majku, kao ni za fetus pri dozama do 575 mikrograma/kg/dan. Mladunci pacova koji su dobijali filgrastim tokom perinatalnog i perioda laktacije, pokazali su kašnjenje u spoljašnjoj diferencijaciji i zaostajanje u rastu (??20 mikrograma/kg/dan) i blago smanjenje stope preživljavanja (100 mikrograma/kg/dan).|If a affected individual or caregiver is not able to demonstrate they can measure the dose and administer the product or service efficiently, you need to consider if the patient is undoubtedly an proper applicant for self-administration of NIVESTYM or whether or not the affected person would take advantage of a distinct NIVESTYM presentation.|Spoljašnje pakovanje je složiva kartonska kutija u kojoj se nalazi pet napunjenih injekcionih špriceva i Uputstvo za lek.|ako se lečite zbog teške hronične neutropenije i imate prisustvo krvi u mokraći (hematurija). Vaš lekar ćeredovno sprovoditi laboratorijske analize Vašeg urina iu isto vreme će kontrolisati vrednosti proteina umokraći (proteinurija).|Slučajevi neželjenih reakcija na plućima, naročito intersticijalna pneumonija, prijavljeni su posle primene G- CSF. Pacijenti sa anamnestičkim podacima o skorašnjoj plućnoj infiltraciji ili pneumoniji mogu imati povećan rizik. Pojava znakova na nivou pluća, kao što su kašalj, groznica-povišena telesna temperatura i dispneja sa radiološkim znacima plućne infiltracije i pogoršanja plućne funkcije mogu biti znaci koji prethode respiratornom distres sindromu kod odraslih (engl.|In case you are acquiring NIVESTYM because you will also be obtaining chemotherapy, your dose of NIVESTYM should be injected at the least 24 hrs before or 24 hours right after your dose of chemotherapy.|Variance in products focus of the NIVESTYM prefilled syringe in comparison to the NIVESTYM vial. When switching patients from your NIVESTYM prefilled syringe towards the NIVESTYM vial, or vice versa, be sure that clients understand the proper volume to get administered Because the concentration of NIVESTYM differs in between the prefilled syringe and also the vial.|ishodom. Potrebno je da lekari budu oprezni pri primeni filgrastima kod pacijenata sa naslednim obeležjem srpastih ćelija ili oboljenjem srpastih ćelija.|Kada Professionalđe interval smanjenja neutrofila na najmanje vrednosti, dnevnu dozu filgrastima treba titrirati u odnosu na odgovor neutrofila na sledeći način:|Kako bi se poboljšala sledljivost (praćenje) biološkog medicinskog proizvoda, ime i broj serije primenjenog leka moraju biti jasno zabeleženi.|Bezbednost i efikasnost filgrastima je slična kod odraslih i kod dece koja primaju citotoksičnu hemioterapiju.|When NIVESTYM is utilized to mobilize PBPCâ???tumor cells could possibly be introduced through the marrow and subsequently collected while in the leukapheresis product or service. The influence of reinfusion of tumor cells has not been effectively researchedâ???and also the limited facts offered are inconclusive.|The pharmacokinetics of filgrastim in pediatric individuals after chemotherapy are just like These in Grownup clients receiving a similar fat-normalized doses, suggesting no age-associated dissimilarities inside the pharmacokinetics of filgrastim products [see Use In Distinct Populations].|Ako se ne primeni odmah, vreme i uslovi čuvanja pre primene predstavljaju odgovornost korisnika i obično ne smeju biti duži od 24 sata na temperaturi od twoºC do8ºC, osimako jerazblaživanje sprovedeno u kontrolisanim i validiranim aseptičnim uslovima.|Stage two: Go ahead and take carton made up of the NIVESTYM prefilled syringe out in the fridge and go away it unopened in your get the job done surface for at least half-hour making sure that it reaches room temperature. Put the original carton with any unused prefilled syringes back again from the fridge.}
Ukoliko Vam se ispolji bilo koja neželjena reakcija, potrebno je da o tome obavestite lekara, farmaceuta ili medicinsku sestru. Ovo uključuje i svaku moguću neželjenu reakciju koja nije navedena u ovom uputstvu.
Acute respiratory distress syndrome (ARDS) has become claimed in patients receiving filgrastim goods. Evaluate patients who establish fever and lung infiltrates or respiratory distress for ARDS. Discontinue NIVESTYM in clients with ARDS.
Glomerulonephritis could take place. Indicators include things like swelling from the experience or ankles, click here dark coloured urine or blood during the urine, or simply a lessen in urine generation. Suggest patients to report signals or indications of glomerulonephritis to their physician immediately [see WARNINGS AND Safety measures].
-da poveća broj belih krvnih ćelija ako patite od ozbiljne hronične neutropenije, da pomogne u prevenciji infekcija,
There's released literature documenting transfer of filgrastim into human milk. There are several circumstance reviews describing using filgrastim in breastfeeding moms without having adverse effects pointed out while in the infants. There are no knowledge on the consequences of filgrastim items on milk output.
The security and efficacy of filgrastim to mobilize autologous peripheral blood progenitor cells for assortment by leukapheresis was supported through the expertise in uncontrolled trials, along with a randomized demo comparing hematopoietic stem mobile rescue making use of filgrastim mobilized autologous peripheral blood progenitor cells to autologous bone marrow (Study eleven).}